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nucleoside analog Forehead osteomata can be removed by burri
2018-11-12
Forehead osteomata can be removed by burring or osteotome chiseling. Comparing these two methods, bone burring is not an efficient method for removing osteomata. It also increases the risk of soft tissue injury or a depressed bony surface. Removal of an osteoma by a curved osteotome is, however, bot
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A neglected but critical component of xenobiotic
2018-11-12
A neglected but critical component of xenobiotic metabolism is the influence of the trillions of microorganisms that inhabit our gastrointestinal tract. Members of the gut microbiota can also influence xenobiotic metabolism by altering host gene niclosamide and producing compounds that interfere wi
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Our xeno free culture conditions
2018-11-12
Our xeno-free culture conditions made single cell passaging possible, and we could also generate EBs from single cell suspensions. Although both hESC lines retained a normal karyotype, we did observe an accumulation of a chromosomal abnormality in one of our cultures. After 13 passages under xeno-fr
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Interestingly we found that IG DMR
2018-11-12
Interestingly, we found that IG-DMR was hypermethylated in the MEFs and mouse tail cells in comparison to ES cells (Figs. 2A and 3SA). This may be a result of IG-DMR imprinting in a tissue-specific manner. Indeed, it had been reported before that IG-DMR is hypermethylated in postnatal neural stem ce
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The effects of TLQP on neurogenesis
2018-11-12
The effects of TLQP-62 on neurogenesis are thus similar to what is reported for antidepressant fluoxetine and serotonin (5-HT), both of which increase the proportion of undetermined Type 2a NPCs marked by Nestin+ and DCX-immunostaining and lacking the radial glial-like morphology (Boku et al., 2011;
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br Materials and methods br Results br Discussion
2018-11-12
Materials and methods Results Discussion Cellular therapeutics may function via either replacement of a lost cell population (e.g. generation of new dopamine neurons or myelinating oligodendrocytes), restoration of a cellular function (e.g. synthesis/secretion of an enzyme in the case of a
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Introduction Alkaline phosphatase ALP is a ubiquitous
2018-11-09
Introduction Alkaline phosphatase (ALP) is a ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values. Examination of expression of ALP at intracellular and extracellular level is a widely-used procedure in both clinical practice and basic rese
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br Results br Discussion Yamanaka factors induce
2018-11-09
Results Discussion Yamanaka factors induce somatic cell reprogramming to iPSCs by promoting spatiotemporal expression of PSC-specific and metabolic genes. However, only a small fraction of these PD 0332991 complete full reprogramming, leaving most cells at an intermediate stage (Chan et al.,
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To study the activation of NSCs by astrocytic
2018-11-09
To study the activation of NSCs by astrocytic calcium waves in a system with reduced complexity, we developed a co-culture system to allow this signaling to be investigated in isolation. Functionally, NSCs stimulated by an astrocytic calcium wave increase their rate of self-renewal as well as their
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The widespread hope for a new era of prevention and
2018-11-09
The widespread hope for a new era of prevention and treatment for chronic neurological disorders, such as stroke, Alzheimer\'s disease, and Parkinson\'s disease, will likely depend on the discovery of new CNS drugs. However, currently over 99% of candidate CNS drugs fail in clinical tests because of
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Then the inequalityalso holds true for
2018-11-09
Then the inequalityalso holds true for constraints (14). Since M is a monoid, we have for any vector . Therefore, it follows from constraint (14) that (Eq. (17) holds because M is a monoid). This in turn results in this inequality following from the assumption we have made: Eq. (14) results in
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In examining why African American patients of midwifery care
2018-11-09
In examining why African American patients of midwifery care had lower prevalence of adverse infant birth outcomes in two of these studies, it is important to assess the significance of “race”. Nancy Krieger defines race/ethnicity as “a social, not biological, category, referring to social groups, o
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At the cellular level DCDC is involved in processes
2018-11-09
At the cellular level DCDC2 is involved in processes such as cellular defense response, dendrite morphogenesis, intracellular signal transduction, regulation of smoothened signaling pathway, regulation of Wnt signaling pathway, and regulation of cilium assembly. At the systems level, DCDC2 is correl
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The exact mechanisms driving the formation of new
2018-11-09
The exact mechanisms driving the formation of new tissue inside the chamber remain to be fully elucidated. When the chamber is placed, the tissues are inevitably stretched generating traction forces that are transmitted to the tissue inside the chamber through the shell perforations. By the phenomen
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br Materials and Methods br Results br
2018-11-09
Materials and Methods Results Discussion Psoriasis is a chronic systemic inflammatory and an autoimmune skin disease. It is histologically characterized by KC hyperproliferation, inflammation, and increased angiogenesis (Bachelez, 2005; Nestle et al., 2009). Although considerable progress i
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