• br Conflict of interest statements br Authors contributions

  2018-11-07

  

  Conflict of interest statements Authors\' contributions Ethics committee approval Acknowledgments We would like to thank J. Visscher (Amsterdam Rheumatology and Immunology Center Department of Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam

• Besides our strongest GWAS signal we also found association

  2018-11-07

  

  Besides our strongest GWAS signal, we also found association signals which have previously been associated with complex diseases including sepsis phenotypes. Genomic variation in CRISPLD2 was reported to be associated with the presence of cleft lips (Mijiti et al., 2015), and recent work showed a de

• The progression of a GBM depends

  2018-11-07

  

  The progression of a GBM depends on invasive growth marked by mesenchymal cell features. It therefore remains a critical priority to expand our knowledge of how the mesenchymal features are modulated. We have employed aSICS as an integrative modeling method to identify regulators of cancer subtypes.

• The role of MeCP in

  2018-11-07

  

  The role of MeCP2 in malignancy has not been extensively researched. Emerging evidence suggests MeCP2 as a key oncogene in cancer development. It was reported a higher level of MeCP2 expression in neoplastic breast tissues than in non-neoplastic tissues (Müller et al., 2003). We previously reported

• Overall our findings indicate that smoking

  2018-11-07

  

  Overall, our findings indicate that smoking is a major driver of molecular heterogeneity in HNSCC, as two HPV− subtypes were clearly more smoking-related, indicated by smoking behavior measures (smoking status, pack years), rates of smoking-related genetic damage (smoking mutation signatures, copy n

• br Materials and Methods br Results

  2018-11-07

  

  Materials and Methods Results Discussion The generation of type I IFN was alternatively postulated as crucial (Dey et al., 2015), important (Abdul-Sater et al., 2013), and also dispensable (Blaauboer et al., 2014; Hanson et al., 2015) for CDN adjuvanticity. In this study we demonstrated tha

• Workflow Mascot Distiller Mascot IRMa hEIDI Spectral

  2018-11-07

  

  Workflow 3: Mascot Distiller/Mascot/IRMa-hEIDI/Spectral Counting. Data were processed automatically using Mascot Distiller software (version 2.4.3.0, Matrix Science). ESI-TRAP was chosen as the instrument, trypsin/P as the enzyme and 2 missed cleavages were allowed. Precursor and fragment mass error

• Numerical treatment For both O and CO diffusivities are iden

  2018-11-07

  

  Numerical treatment. For both O2 and CO2, diffusivities are identified by fitting a dedicated mathematical model to the experimental kinetic curve (space-dependent profile or time-dependent profile). This identification step is performed using a routine (“lsqnonlin”) of Matlab® software. Acknowle

• br Acknowledgement br Data Descriptive values

  2018-11-07

  

  Acknowledgement Data Descriptive values of physical capacity-related variables, NT-ProBNP, cardiopulmonary exercise capacity, PA levels and HRQoL of PAH patients involved in the RCT [2] (ClinicalTrials.gov ID: NCT02288442) conducted from January 2015 to June 2016 at the Hospital 12 de Octubre

• br Results QR codes prepared from S rDNA sequences

  2018-11-07

  

  Results QR codes prepared from 16S rDNA sequences of Lysinibacillus species were unique. Any user can scan QR code using a smart phone and retrieve the sequence (Fig. 1). CGR and FCGR were used for visual interpretation of the appearance of nucleotides in 16S rRNA genes. Each CGR image has four

• Previous preclinical research on brain development and disea

  2018-11-07

  

  Previous preclinical research on gsk-3 development and disease has primarily assessed morphological changes or alterations at the receptor level. These studies have yielded critical information about adolescent biology and behavior. There is little known, however, about real-time dynamics of neuron

• The current study sought to expand on this body

  2018-11-07

  

  The current study sought to expand on this body of literature by examining neural activation to reward in a group of binge-drinking adolescents compared to alcohol/drug-naïve controls using a prospective, longitudinal approach. Adolescents performed a modified version of the Wheel of Fortune (WOF) t

• ap1 While there are a number of reports

  2018-11-07

  

  While there are a number of reports of enhanced coupling between subcortical and cortical structures in adolescence, there have also been some reports of a decrease in functional coupling between amygdala and orbitofrontal activity in adolescence (Spielberg et al., 2014b). Our framework suggests tha

• Current findings are broadly convergent with

  2018-11-07

  

  Current findings are broadly convergent with, yet also clearly distinct from, our previous report (drawn from an overlapping sample) (Price et al., 2014), in which global measures of anxiety (presence of clinical anxiety; greater overall anxiety severity) were linked to decreased integration of resp

• The effects of inadequate and abusive care

  2018-11-07

  

  The effects of inadequate and abusive care on the etiology of neurobehavioral deficits remain poorly understood, although animal models have attempted to add some insight into this complex issue (Gunnar et al., 2015; Hennessy et al., 2006, 2009; Hostinar et al., 2014; Opendak and Sullivan, 2016; Rai

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