• Malignant tumors in solid and bowel organs

  2018-11-06

  

  Malignant tumors in solid and bowel organs were different with regard to tumor spreading or in tumorigenesis. Distal bowel intramural spread is present within 1 cm distally from the visible tumor in a substantial proportion of patients. For these reasons, for patients with low-lying cancer who are u

• The essence of obesity is

  2018-11-06

  

  The essence of obesity is that the energy intake is larger than that consumption. When the amount of glucose used as direct energy material excesses that of daily requirement in the body, the extra glucose is transferred to the cells of liver or skeletal muscle and is transformed into liver- or musc

• br Experimental br Results and discussions The modulation

  2018-11-06

  

  Experimental Results and discussions The modulation of the dynamic sensing range of electrochemical aptasensor is of great significance but facing great challenges. The design and principle of the extraordinary tunable dynamic range of the electrochemical aptasensor is shown in Scheme 1, the k

• Results br Discussion In this study we described the differe

  2018-11-06

  

  Results Discussion In this study, we described the differentiation of hiPSCs into efficient functional ECs and compared them with hESC-ECs. We have found that hiPSCs, similar to hESCs, can be differentiated into ECs by the use of a sequential combination of FLK1-positive (EPC marker) and CD31-po

• In our evaluation of the G q PLC PKC

  2018-11-06

  

  In our evaluation of the Gαq-PLCβ-PKC pathway, treatment with agonist (kisspeptin), or a negative allosteric modulator (MPEP) of specific Gα-q/11-coupled GPCRs had no significant effects on either total cell growth/viability or undifferentiated hESC renewal, despite detection of transcripts encoding

• Recently our group elucidated the

  2018-11-06

  

  Recently, our group elucidated the role of the endothelium and secretion of angiocrine factors in the expansion of mouse and human HSCs (Butler et al., 2010a, 2010b; Kobayashi et al., 2010). We developed a model of endothelial Aminoallyl-dCTP - Cy3 with autonomous Akt-activation (HUVECs-E4ORF1, refe

• Previous in vitro characterization of compensatory TSC

  2018-11-06

  

  Previous in vitro characterization of compensatory TSC differentiation was performed at 20% O2 with a dose of benzopyrene or hyperosmolar stress that activated maximal stress enzyme (Zhong et al., 2010; Xie et al., 2010). When O2 levels are optimized, the highest growth and the least stress (activat

• We have demonstrated that neuregulin induced proliferation o

  2018-11-06

  

  We have demonstrated that neuregulin-induced proliferation of differentiated adult mouse and rat cardiomyocytes occurs primarily in the mononucleated portion (Bersell et al., 2009). Most adult zebrafish cardiomyocytes are mononucleated, which is consistent with their significant proliferative activi

• Induced pluripotent stem cells have emerged as powerful

  2018-11-06

  

  Induced pluripotent stem 69 8 have emerged as powerful tool for many applications including disease modelling, drug screening and cell based therapies (Takahashi and Yamanaka, 2016). Therefore, increased efficiency of cell reprogramming is beneficial as it could help reduce the time required to pro

• The negative regulation of Zac expression by SOXB transcript

  2018-11-06

  

  The negative regulation of Zac1 expression by SOXB1 transcription factors combined with the decrease of Sox2 expression as the levels of Zac1 increase suggest that ZAC1 and SOXB1 factors could act as a cross-repressive genetic switch governing the acquisition of distinct cellular identities (Enver e

• br Materials and methods br Results br

  2018-11-06

  

  Materials and methods Results Discussion Since the initial report of iCM reprogramming in vitro (Ieda et al., 2010) and in vivo (Inagawa et al., 2012; Qian et al., 2012; Song et al., 2012), there have been considerable efforts to enhance the efficiency of direct cardiac reprogramming. One o

• Many previous studies examining mutagenesis in pluripotent c

  2018-11-06

  

  Many previous studies examining mutagenesis in pluripotent cells have utilized UV radiation to induce DNA damage (Bártová et al., 2011; Martins-Taylor and Xu, 2012; Momcilović et al., 2009; Bañuelos et al., 2008; de Waard et al., 2008; Maynard et al., 2008). Damage of this sort is normally repaired

• A lag by even a few milliseconds during neuronal activation

  2018-11-05

  

  A lag by even a few milliseconds during neuronal activation can sometimes completely transform the response signal affecting the rest of the nervous system, Optogenetics fundamentally enhances the temporal precision of traditional manipulations used for studying the roles of specific genes in cells,

• Analysis of the data in Fig b shows

  2018-11-05

  

  Analysis of the data in Fig. 3b shows that the shape of the (222) reflection virtually does not change and corresponds to the instrumental resolution at all temperatures. The right shoulder of the (310) peak exhibits slight differences from the instrumental resolution even at high temperatures, whic

• One possible reason why lasing characteristics

  2018-11-05

  

  One possible reason why lasing characteristics deteriorate at high injection levels in materials with a low band gap may be non-radiative Auger recombination, which can have a resonant character under certain conditions, leading to a marked increase in the recombination rate [3]. Studying the recomb

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