• An EMBO conference on cell

  2018-10-24

  

  An EMBO conference on cell therapy and its clinical applications The topics Given the broad and sometimes ill-defined distinctions among the various disciplines, we decided to focus on both allogeneic and autologous genetically corrected cell therapy, with the exclusion of “in vivo” gene therapy

• The dedifferentiation of lineage committed cells into more p

  2018-10-24

  

  The dedifferentiation of lineage-committed i was reading this into more primitive stem-like states during transplantation is similar to the cell-state transitions that occur during tumor initiation (Keller et al., 2010). For example, preceding the onset of basal cell carcinoma, adult tumor-initiati

• Proper functioning of the RPE is important for maintaining

  2018-10-24

  

  Proper functioning of the RPE is important for maintaining the health and integrity of the outer retina, photoreceptors, and choriocapillaris. Healthy RPE cells play many crucial roles in the retina, including transportation of nutrients such as glucose or vitamin A from blood to the photoreceptors,

• The fast advances in protocol and mechanism studies have mad

  2018-10-24

  

  The fast advances in protocol and mechanism studies have made iN direct reprogramming a promising strategy to study and treat neural diseases. However, only a few human somatic cell types have been tested for iN induction. Whether the protocols for these somatic MRS 2578 are generally applicable t

• br Experimental Procedures br Author Contributions M A plann

  2018-10-24

  

  Experimental Procedures Author Contributions M.A. planned and performed the experiments and wrote the manuscript. T.N. helped in performing CTL redifferentiation experiments. S.Y. provided scientific discussion and technical support. T.Y. provided plasmids and helped in generating lentivirus v

• br Results br Discussion The interest

  2018-10-24

  

  Results Discussion The interest in directed cell-fate determination in stem cell biology and regenerative medicine has been increasing over the years. However, due to the complexity of GRNs, identification of cell-fate determinants and their functionally important subnetworks (GRN motifs) that

• buy 1-Deoxynojirimycin br Results br Discussion Here we perf

  2018-10-24

  

  Results Discussion Here we performed genome-wide ATAC-seq, ChIP-seq, and RNA-seq profiling to define the immediate-early molecular events that catalyze fibroblast-to-neuron reprogramming by NEUROG2 and small molecules. While NEUROG2 is sufficient to reprogram glial buy 1-Deoxynojirimycin into

• br Experimental Procedures br Author Contributions

  2018-10-24

  

  Experimental Procedures Author Contributions The study was conceived and designed by H.W.C and J.T.D. H.W.C. carried out the majority of experiments, performed data analysis, and created the figures. J.Y.J., Y.J.H., G.W., H.S., and J.S.K. performed some data analysis. Oct4-ΔDE-RFP vector was c

• G lucidum is a medicinal mushroom well known for

  2018-10-24

  

  G. lucidum is a medicinal mushroom well known for its legendary anti-aging benefits. Our findings that GLP not only promote NPC proliferation but also reduce amyloid deposits provide potential underlying mechanisms of its anti-aging effects. Extract of G. lucidum has also been reported to inhibit th

• p2y receptor An important yet unanswered question in ALS dis

  2018-10-24

  

  An important yet unanswered question in ALS disease pathophysiology is the targeted loss of MNs but relative sparing of non-MNs. Strikingly, we found that the AP1 complex member JUN was expressed at significantly higher levels in MNs compared with non-MNs, suggesting a role of JUN in maintaining MN

• To evaluate global gene expression patterns in the mutant ce

  2018-10-24

  

  To evaluate global gene expression patterns in the mutant cells, we performed RNA sequencing (RNA-seq) on control and the three RB1−/− clones. Of the expressed transcripts, 4.8% were either 2-fold upregulated or downregulated in the RB1−/− clones. In contrast to the absence of pRB due to frameshift

• The gene of the sigma receptor is located

  2018-10-24

  

  The gene of the sigma-1 receptor is located on chromosome 9p13, known due to its being associated with psychotic disorders [6]. The sigma-1 receptor, with its small size (223 amino-acid residue), binds with medium or high affinity to a wide range of chemical compounds of very different structural cl

• Our research team has already reported on associations

  2018-10-24

  

  Our research team has already reported on associations between poorer physical and mental health outcomes in later life and higher reported warzone stress exhibited by the deployed nurses in this daminozide cohort. We found that their PTSD symptoms mediated the effect of warzone stressors on their

• While in developed countries a home death is considered

  2018-10-24

  

  While in developed countries, a home death is considered a good death, however, in sub-Saharan African countries this dna synthesis inhibitors may have a different implication in that a person who dies at home could have failed to access and utilize health care services. Conversely, an individual w

• The average schooling of the two groups

  2018-10-23

  

  The average schooling of the two groups is noteworthy; individuals with health problems have on average 5.6 years of schooling, while individuals without health problems have a much higher average schooling, 8.3 years. This result has been found in several studies. The relationship between health an

15788 records 1048/1053 page Previous Next First page 上5页 10461047104810491050 下5页 Last page