• br Introduction Stroke is a devastating condition that cause

  2024-02-06

  

  Introduction Stroke is a devastating condition that causes cognitive and motor dysfunction, neurodegenerative diseases and even acute death, and is a leading cause of mortality and morbidity worldwide (Chen et al., 2014a, Wang et al., 2016). Thus, exploration or identification of novel therapeuti

• br Autophagy in the central nervous system The autophagic

  2024-02-06

  

  Autophagy in the central nervous system The autophagic process appears to be very important for the cells of the central nervous system, as it allows to maintain the functional integrity of the nervous tissue. Indeed macroautophagy is involved in the regulation of homeostasis of the CNS, playing

• In addition to calpain I activity cathepsin

  2024-02-05

  

  In addition to calpain I activity, cathepsin activities have been proven to be linked to apoptotic signaling. Cathepsin B and cathepsin D are two of the most abundant and well-investigated lysosome acid-dependent proteases that are involved in the apoptotic regulation (Ferri & Kroemer, 2001). Cathep

• br STAR Methods br Author Contributions br Acknowledgments

  2024-02-05

  

  STAR★Methods Author Contributions Acknowledgments We thank Craig D. Wenger and Neva C. Durand for helpful advice, guidance, and discussions. D.H.P. is supported by the NIH National Human Genome Research Institute (NHGRI) (grant R00HG008662) and the Damon Runyon Cancer Research Foundation (D

• Of the cardiovascular studies involving

  2024-02-05

  

  Of the cardiovascular studies involving ARBs, 3 reported renal outcomes. In the Losartan Intervention For Endpoint study, albuminuria was observed less frequently in the losartan than in the atenolol arm (7% vs. 13%; p=0.002) (5). In the Candesartan Antihypertensive Survival Evaluation in Japan tria

• Inhibition of autophagy has been shown to alleviate

  2024-02-05

  

  Inhibition of autophagy has been shown to alleviate neuronal damage after cerebral ischemia, both in cell culture and rodent models (Koike et al., 2008, Li et al., 2015, Wang et al., 2016, Zhang et al., 2014, Zheng et al., 2014). Therefore, blockage of autophagy is a potential target for prevention

• Lee et al have demonstrated that APPL associates with AdipoR

  2024-02-05

  

  Lee et al. have demonstrated that APPL1 associates with AdipoR1 in Hek293 A-366 where both proteins have been overexpressed with suitable tags [16]. In contrast to recent data the formation of this complex is not enhanced by exogenous adiponectin [16], [33]. Knock-down of APPL1 reduces the level of

• If overexpression of ADK is sufficient to induce spontaneous

  2024-02-05

  

  If overexpression of ADK is sufficient to induce spontaneous seizures, then reduction of ADK in engineered mice should prevent epileptogenesis. The generation of mice with moderately reduced levels of ADK in brain rather than complete ADK deficiency seems to be essential, since several lines of evid

• Luciferase Immunoprecipitation Systems LIPS which

  2024-02-04

  

  Luciferase Immunoprecipitation Systems (LIPS), which utilizes recombinant antigens fused to the enzyme reporter Renilla luciferase (Ruc) to detect patient antibodies, provides a unique platform to investigate ampk pathway directed against a variety of antigenic targets [25]. Previously, LIPS has be

• The central problem in amnesia developing following impairme

  2024-02-04

  

  The central problem in amnesia developing following impairment of long-term memory consolidation or reconsolidation is a question of the underlying mechanisms, whether it is caused by impairment of retrieval or memory storage mechanisms [3,8,9,[15], [16], [17], [18]]. To answer this question, severa

• br Extracellular domain architecture The

  2024-02-04

  

  Extracellular domain architecture The extracellular region of GABAB receptor exists in a heterodimeric configuration regardless of interactions within the rest of the protein (Geng et al., 2012, Liu et al., 2004, Nomura et al., 2008). The extracellular domains of the GABAB1 and GABAB2 subunits ar

• CORT induced hippocampal damage has been

  2024-02-04

  

  CORT-induced hippocampal damage has been implicated in depression, aging and long-term glucocorticoid therapy. Therefore, finding a drug that can protect hippocampal neurons from the adverse effects of CORT could have significant clinical benefits. In this regard, we tested the potential protective

• Mitochondrial DNA Isolation Kit br Apelin The APJ receptor

  2024-02-04

  

  Apelin The APJ receptor ligand apelin firstly in 1998 was segregated from bovine stomach tissue. Human preproapelin gene located on chromosome Xq25–26.1. The apelin preproproteins consist of 77 amino Mitochondrial DNA Isolation Kit residues that are cleaved into biologically active C-terminal fr

• Experimentally the ECD spectrum of showed three ECD bands po

  2024-02-04

  

  Experimentally, the ECD spectrum of 1 showed three ECD bands: positive ones at 260 and 200nm, and a negative one at 230nm (Fig. 4). Meanwhile, there is only one broad positive ECD band starting from 300nm in the ECD spectrum of 2. ECD spectra of 1 and its derivatives attracted great interest because

• br Steroidogenesis in the skin The synthesis of steroid

  2024-02-04

  

  Steroidogenesis in the skin The synthesis of steroid hormones takes place in many tissues of which the adrenal glands, ovaries, testis, placenta and Birinapant receptor are considered to be classical steroidogenic organs. Nevertheless, skin constitutes an important peripheral steroidogenic tissu

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