• In the current study Olfml knockdown increased YAP but

  2022-08-04

  

  In the current study, Olfml1 knockdown increased YAP but decreased the respective target genes of canonical Wnt signaling and Hedgehog signaling, Axin2 and Gli1. YAP suppresses canonical Wnt via binding to Dishevelled and/or β-catenin [[39], [40], [41], [42]]. Tariki et al. reported that adenovirus-

• br Conclusions br Acknowledgements This work was supported b

  2022-08-04

  

  Conclusions Acknowledgements This work was supported by grants from the Polish National Science Center: 2014/14/E/NZ1/00139 (to A. Jazwa-Kusior) and 2015/17/N/NZ1/00041 (to M. Tomczyk) and National Centre for Research and Development (STRATEGMED2/269415/11/NCBR/2015) (to J. Dulak). Faculty of

• Several classes of small molecules that modulate CDK activit

  2022-08-04

  

  Several classes of small molecules that modulate CDK8 activity have been reported in the patent literature (Fig. 1). A quinazoline derivative, Senexin B (SNX2-1–165, 1), showed CDK8 enzyme inhibitory activity with an IC50 value of 24–50 nM in different assay, and displayed potent, selective enzymati

• Previous studies have established that phosphorylation

  2022-08-04

  

  Previous studies have established that phosphorylation of GC-B is required for activation of GC-B. Conversion of all six chemically determined serine and threonine phosphorylation sites in GC-B to alanines produced a properly folded enzyme that retained GC activity under synthetic detergent activati

• raas inhibitor As comparators compounds and were made using

  2022-08-04

  

  As comparators, compounds and were made using the pyrazolopyridine core with the CF triazole attached. The 2-fluorophenyl group was replaced with the methylpyrimidine in compound . The potency of these compounds were very good and compound looks attractive from a physicochemical perspective as it

• GCIPs are highly conserved Ca binding proteins first

  2022-08-04

  

  GCIPs are highly conserved Ca2+-binding proteins first discovered in the frog [42] and later in teleost [9]. With regard to gene structure, sequence conservation, and function, GCIPs are evolutionarily related to the GCAPs. The GCIP genes have acquired an additional intron in the N-terminal region w

• br Competing interests br Introduction An effective

  2022-08-04

  

  Competing interests Introduction An effective vaccine against the Human immunodeficiency virus (HIV) is still to be created, even though many strategies have already been tried [1]. Antibodies against a vaccine antigen must be either neutralizing or inducing cellular cytotoxicity [1]. It is kn

• Gp induces cell death by apoptotic mechanisms and increases

  2022-08-04

  

  Gp120 induces cell death by apoptotic mechanisms and increases intracellular Ca, and activates messengers related to cell death. Intracellular mechanisms of neuronal damage are mainly a consequence of the activation of the N-methyl-d-aspartate receptor (NMDAR) [2], [5], which induces excitotoxicity

• br Introduction Verticillium dahliae Kleb is a soil

  2022-08-04

  

  Introduction Verticillium dahliae (Kleb.) is a soil-borne fungal pathogen that is able to infect hundreds of plant species, and causes vascular wilt disease [1], [2]. In nature, the infection of V. dahliae initiates from the germination of resting structures called microsclerotia [3]. The germina

• Histamine functions as a key

  2022-08-03

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, ARQ 621 is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pathway (

• The post translational modification O

  2022-08-03

  

  The post-translational modification O-GlcNAcylation is also dependent upon glucose fluctuations. O-GlcNAcylation has been linked to insulin resistance and glucose toxicity in diabetes and its comorbidities [11]. O-GlcNAcylation is a dynamic modification tightly regulated by the nutritional sensor UD

• Amiloride HCl The HH signaling has also been implicated in t

  2022-08-03

  

  The HH signaling has also been implicated in the regulation of cancer stem Amiloride HCl (CSC) by promoting their self-renewal [53]. Activated HH signaling has been identified in CSCs of many solid tumors, such as glioblastoma, breast, colon, pancreatic cancer, melanoma, and hematological malignanc

• The diverse biochemistry of zinc means that in many cases

  2022-08-03

  

  The diverse biochemistry of zinc means that, in many cases, more than one factor (or pathway) is at play. Whilst catalytic Zn2+ sites are now typically well-understood, the recognition that Zn2+ levels regulate the function of many cell types has led to vigorous interest in the fate and role of mobi

• Till date the first line treatment of T DM

  2022-08-03

  

  Till date, the first line treatment of T2DM is oral metformin followed by oral sulfonylureas, dipeptidyl peptidase-IV-inhibitors, and TZDs. As the disease progresses, injectable glucagon-like peptide-I analogues or ultimately insulin become necessary to maintain glycaemic control. Despite the establ

• br STAR Methods br Introduction Arsenite is a well

  2022-08-03

  

  STAR★Methods Introduction Arsenite is a well-recognized toxic metalloid that commonly presents in the natural environment. Chronic exposure to arsenite can lead to a wide range of adverse health effects to human, including cancers, cardiovascular diseases, diabetes, skin lesion and neurodegene

15873 records 387/1059 page Previous Next First page 上5页 386387388389390 下5页 Last page