• br Conclusion br Conflict of interest br Acknowledgements br

  2022-01-07

  

  Conclusion Conflict of interest Acknowledgements Introduction The brain contains abundant fatty acids, which serve as constituents of membranes and as an energy source. In addition, fatty acids and their metabolites contribute to signal transduction between neurons or neurons and glial c

• Enhancer of Zeste Homolog EZH is a core

  2022-01-07

  

  Enhancer of Zeste Homolog 2 (EZH2) is a core component of the Polycomb Repressive Complex2 (PRC2) which also includes SUZ12 and EED. PRC2 represses gene transcription through trimethylation of Lys27 of histone H3 (H3K27), and contribute to the maintenance of cell identity, ONX0914 receptor regulati

• br The SRP SR Heterodimer GTPase Tangos Drive Co Translation

  2022-01-07

  

  The SRP/SR Heterodimer: GTPase Tangos Drive Co-Translational Protein Targeting SRP and SR mediate a universally conserved protein targeting pathway responsible for the delivery of 25–30% of newly synthesized proteome to the eukaryotic endoplasmic reticulum (ER) or the bacterial plasma membrane 11

• The simple carrier model for GLUT transport activity propose

  2022-01-06

  

  The simple carrier model for GLUT1 transport activity proposes that the transporter alternates between an outward facing glucose binding site and an inward, cytoplasmic, facing glucose binding site. Cytochalasin B is an endofacial inhibitor and appears to preferentially bind to the open, inward faci

• In this study we investigated the contribution

  2022-01-06

  

  In this study, we investigated the contribution of GCK, G6PC, and PCK expression to glycemia in diabetes. We examined liver tissue from 40 obese subjects: 12 had normal glucose tolerance (NGT) and 28 had type 2 diabetes. Materials and methods Results Discussion This study aimed to investig

• Pattern recognition receptors key elements in

  2022-01-06

  

  Pattern recognition receptors - key elements in the innate immune response Every day, human beings are exposed to a broad range of microbes and foreign substances. Most of them are entirely harmless, however, some are pathogenic and have the potential to cause severe harm. The distinction between “

• br Experimental procedures br Results br Discussion This stu

  2022-01-06

  

  Experimental procedures Results Discussion This study demonstrates that the genetic disruption or pharmacological inhibition of FAAH completely prevented all manifestations of pain symptoms in an NTG-induced migraine animal model. Thus, FAAH disruption or blockade abolished the activation o

• Macrophage populations are prominent in active

  2022-01-06

  

  Macrophage populations are prominent in active IBD (Strober and James, 1986) as compared to healthy donors. Further, percentages of macrophages are increased in DSS-induced colitis (Grose et al., 2001, Ogawa et al., 2004). IBD is also linked to an influx of neutrophils and depletion of neutrophils b

• The site of metastasis in breast cancer

  2022-01-06

  

  The site of metastasis in breast cancer often contributes to the patient’s OS. Patients with bone metastasis from their breast cancer often have a notably increased survival over patients with visceral or GDC-0084 metastasis. In this analysis, ER+/HER2+ patients were noted to have a higher rate of

• br STAR Methods br Acknowledgments The authors would like to

  2022-01-06

  

  STAR★Methods Acknowledgments The authors would like to acknowledge Genentech DNA Sequencing, Biologics Resource, Oligo, FACS, and Bioinformatics groups for their help with the project. Our thanks to Craig Cumming and Sophia Maund for facilitating our access to large-scale mutation data. We als

• br Pathophysiology of glaucoma Glaucoma is a

  2022-01-05

  

  Pathophysiology of glaucoma Glaucoma is a group of optic neuropathies defined by progressive degeneration of RGCs and their anderson kpt in the optic nerve, which leads to irreversible loss of vision [3,8,9]. RGC degeneration is often significantly advanced before changes in visual acuity and ev

• Annexin A ANXA a member of annexin superfamily

  2022-01-05

  

  Annexin A7 (ANXA7), a member of annexin superfamily, is a Ca2+- and phospholipid-binding protein and possesses GTPase activity [5,6]. The ANXA7 gene is located on human chromosome 10q21, where multiple potential tumor suppressor genes exist. Homozygous ANXA7 (−/−) knockout mice showed a lethal pheno

• br Materials and methods br Results Using an gene Th

  2022-01-05

  

  Materials and methods Results Using an 84 gene Th1-Th2-Th3 cytokine profile, 17 genes were significantly up-regulated in PBMC one week post-marathon compared to pre-marathon samples (Table 1). Eight genes were down-regulated among various subjects but none consistently enough to achieve statis

• The treatment target which aims at diagnosing of HIV

  2022-01-05

  

  The “90-90-90 treatment target” which aims at diagnosing 90% of HIV-infected individuals, treating 90% of those diagnosed and achieve viral suppression for 90% of treated individuals, is a key strategy to achieve one of the sustainable development goals (SDG) of ending AIDS as a public health threat

• VPS34-IN1 Historically a role for the prefrontal cortex

  2022-01-05

  

  Historically, a role for the prefrontal cortex in spatial working memory has been repeatedly claimed (for review, see Kolb, 1984). Older studies using traditional, non-fibre-sparing lesions (e.g. aspiration lesions) often resulted in spatial alternation deficits. In contrast, more recent studies emp

16608 records 556/1108 page Previous Next First page 上5页 556557558559560 下5页 Last page