• We had previously observed a decrease in unspliced intron

  2020-07-31

  

  We had previously observed a decrease in unspliced, intron-containing HIV mRNA in infected murine cells (Coskun et al., 2007, Coskun et al., 2006, Elinav et al., 2012). The presence of human chromosome 2 in murine cells largely reversed this defect and significantly enhanced infectious virus product

• In our recent work we established a different and new

  2020-07-31

  

  In our recent work, we established a different and new strategy to overcome the immunogenicity problem. We showed that isolation of a novel form of the protein used with different epitops could also minimize the patient immune response. We showed that the antibody of one form of the enzyme does not

• Abdominal aortic aneurysm AAA is considered a major health c

  2020-07-31

  

  Abdominal aortic aneurysm (AAA) is considered a major health concern and is associated with extremely high rates of mortality in case of aortic rupture. The main pathophysiologic mechanisms leading to aortic dilation include the degradation of the extracellular matrix (ECM) components, such as colla

• br Oxysterol Metabolism and Molecular Targets br Oxysterols

  2020-07-31

  

  Oxysterol Metabolism and Molecular Targets Oxysterols in Metabolic Syndrome The Oxysterol System: A Potential Target to Tackle MetS Concluding Remarks The question of ⿿is it possible to interfere with the ⿿oxysterome⿿ in order to treat MetS?⿿ is complex. Pharmacologically modulating the

• Data about the ability of non

  2020-07-31

  

  Data about the ability of non-conventional ligands to operate class-A GPCRs have been accumulating. Specifically, increasing evidence indicates that oxysterols, oxidized derivatives of cholesterol, are involved in many activities that are not strictly associated with cholesterol metabolism and may a

• EMI regulates the coupling of

  2020-07-31

  

  EMI1 regulates the coupling of mitosis and DNA replication [81]. Briefly, after Calyculin A divide, APC/CCDH1 activity must be restrained. Although this is ultimately achieved by CDH1 phosphorylation, the required CDK activity is too low in G1 due to APC/CCDH1-dependent degradation of cyclins. Thus,

• Coactivator binding induces substantial APC C conformational

  2020-07-31

  

  Coactivator binding induces substantial APC/C conformational changes that globally shift the platform and catalytic core into proximity of the substrate-binding module and increase the mobility of domains contributing to catalysis 21, 24 (Figures 2 A and 4 B). Most strikingly, repositioning of APC4

• Three new trans P Hs AlP H MiP

  2020-07-31

  

  Three new trans-P4Hs (AlP4H, MiP4H and ScP4H) discovered by a genome mining approach in this study were all located in branch A containing DaP4H sequence. Although another three candidates from Amycolatopsis mediterranei, Bradyrhizobium sp. ORS285 and O. indicum were successfully expressed as solubl

• ha141 receptor Conventional CMV IgG avidity assays have prov

  2020-07-31

  

  Conventional CMV IgG avidity assays have proved to be a helpful tool to date infection in pregnant women with positive CMV IgG and IgM; however, they give an intermediate or inconclusive result in 12–25% of cases, depending on the ha141 receptor studied and the method used (Enders et al., 2014, Ler

• Few studies have been reported on

  2020-07-31

  

  Few studies have been reported on the selectivity of prolyl hydroxylase inhibitors for different types of prolyl hydroxylases, including for the PHD inhibitors in clinical trials.3, 16 This is important, especially for applications in the treatment of chronic diseases, e.g. anaemia.1, 2, 3 A recent

• br Mitochondria and neurodegeneration Contribution of the

  2020-07-30

  

  Mitochondria and neurodegeneration: Contribution of the mitochondrion to the neurodegenerative disorders such as AD, PD and HD candidates this organelle as therapeutic target. Mitochondria have their own circular DNA with 16,569 HPK 56 pairs. Some components of the respiratory system, specific r

• br Conclusion Several classes of models have

  2020-07-30

  

  Conclusion Several PP 3 sale of models have successively emerged since the 1970s. Three main models describing Ca2+ binding to CaM are now surviving: All three models explain most of the experimental results obtained up to now. However, the two first ones, due to the symmetrical behavior of the

• Although the overall profile of was encouraging we pursued i

  2020-07-30

  

  Although the overall profile of was encouraging, we pursued its optimization based on SAR studies imported from a novel class of compounds in which the sulfonamide moiety of MK-7246 was replaced by an amide group. Potential liabilities related to the presence of a sulfonamides group (i.e., allergic

• Additionally of outmost important is the location of the

  2020-07-30

  

  Additionally, of outmost important is the location of the different CpG islands in relation to the transcription starting site (TSS) of the promoter as well as their interaction with transcription activators or repressors. It has been shown that methylation at the downstream region of the TSS in the

• br Involvement of p and Sp To investigate

  2020-07-30

  

  Involvement of p53 and Sp1 To investigate transcriptional regulation of the COX-2 gene in response to HNE, Kumagai et al. [15] examined whether the HNE-induced COX-2 expression was mechanistically linked to the expression of p53, a transcription factor that regulates the response to a variety of

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