• Induced pluripotent stem cells have emerged as powerful

  2018-11-06

  

  Induced pluripotent stem 69 8 have emerged as powerful tool for many applications including disease modelling, drug screening and cell based therapies (Takahashi and Yamanaka, 2016). Therefore, increased efficiency of cell reprogramming is beneficial as it could help reduce the time required to pro

• The negative regulation of Zac expression by SOXB transcript

  2018-11-06

  

  The negative regulation of Zac1 expression by SOXB1 transcription factors combined with the decrease of Sox2 expression as the levels of Zac1 increase suggest that ZAC1 and SOXB1 factors could act as a cross-repressive genetic switch governing the acquisition of distinct cellular identities (Enver e

• br Materials and methods br Results br

  2018-11-06

  

  Materials and methods Results Discussion Since the initial report of iCM reprogramming in vitro (Ieda et al., 2010) and in vivo (Inagawa et al., 2012; Qian et al., 2012; Song et al., 2012), there have been considerable efforts to enhance the efficiency of direct cardiac reprogramming. One o

• Many previous studies examining mutagenesis in pluripotent c

  2018-11-06

  

  Many previous studies examining mutagenesis in pluripotent cells have utilized UV radiation to induce DNA damage (Bártová et al., 2011; Martins-Taylor and Xu, 2012; Momcilović et al., 2009; Bañuelos et al., 2008; de Waard et al., 2008; Maynard et al., 2008). Damage of this sort is normally repaired

• A lag by even a few milliseconds during neuronal activation

  2018-11-05

  

  A lag by even a few milliseconds during neuronal activation can sometimes completely transform the response signal affecting the rest of the nervous system, Optogenetics fundamentally enhances the temporal precision of traditional manipulations used for studying the roles of specific genes in cells,

• Analysis of the data in Fig b shows

  2018-11-05

  

  Analysis of the data in Fig. 3b shows that the shape of the (222) reflection virtually does not change and corresponds to the instrumental resolution at all temperatures. The right shoulder of the (310) peak exhibits slight differences from the instrumental resolution even at high temperatures, whic

• One possible reason why lasing characteristics

  2018-11-05

  

  One possible reason why lasing characteristics deteriorate at high injection levels in materials with a low band gap may be non-radiative Auger recombination, which can have a resonant character under certain conditions, leading to a marked increase in the recombination rate [3]. Studying the recomb

• One possible reason why lasing characteristics

  2018-11-05

  

  One possible reason why lasing characteristics deteriorate at high injection levels in materials with a low band gap may be non-radiative Auger recombination, which can have a resonant character under certain conditions, leading to a marked increase in the recombination rate [3]. Studying the recomb

• br Funding and conflict of interest

  2018-11-05

  

  Funding and conflict of interest statements Acknowledgements We would like to acknowledge funding received from the Canadian Institutes of Health Research (award number GSD-134926) and the Lawson Foundation, Canada (grant number GRT 2011-013). We would also like to thank Dr. Mieke Koehoorn for

• The fluoroquinolone group gemifloxacin is one

  2018-11-05

  

  The fluoroquinolone group (gemifloxacin) is one of the most important pharmaceuticals used universal wide for humans and veterinary purposes. The occurrence of broad-spectrum antibiotics similar to these in aquatic environments may approach serious threats to the ecosystem and human health by making

• Other factors like the charge difference electronic distinct

  2018-11-05

  

  Other factors like the charge difference, electronic distinction and magnetic topoisomerase inhibitor are usually associated with the substitution of different cations with different sizes, so that their effects on the correlation pattern between the K and composition are hard to separate and much

• Circulating levels of vitamin K are rarely

  2018-11-05

  

  Circulating levels of vitamin K are rarely measured in clinical practice, because of the complexity of the assay and the lack of a high-throughput method (Riphagen et al., 2015), and because b catenin inhibitor levels only reflect dietary intake (vitamin K1; phylloquinone) and production by the gut

• br Author Contributions br Conflicts of

  2018-11-05

  

  Author Contributions Conflicts of Interest Introduction Severe influenza occurs each winter especially in high-risk groups such as young children, older adults, patients with pulmonary conditions, inflammatory conditions, malignancies, and pregnant women (Newton et al., 2000; Schanzer et al

• br Discussion By excluding heat and cold wave studies we

  2018-11-05

  

  Discussion By excluding heat and cold wave studies, we show that temperature exposure in time-series spanning three or more years/seasons is associated with increased risk for many cause-specific health outcomes in the elderly. Adverse heat effects are concerning because an increase in mean world

• br Introduction Today about of treated persons living with H

  2018-11-05

  

  Introduction Today, about 90% of treated persons living with HIV are aviremic (Delaugerre et al., 2015). Yet, 6 to 24% of these virologic responders do not restore their CD4 count as they should, exposing them to the risk of immune deficiency-linked morbidities (Corbeau and Reynes, 2011). The mai

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