• Ectopic bone formation is a standard activity

  2018-10-22

  

  Ectopic bone formation is a standard activity of human BMSC on calcium phosphate ceramics, such as β-tricalcium phosphate (β-TCP) and hydroxyapatite (HA)/TCP (Krebsbach et al., 1997; Kasten et al., 2005, 2008; Mankani et al., 2006; Sacchetti et al., 2007; Janicki et al., 2010, 2011), particularly wh

• Introduction The degree to which embryonic stem cells ESCs r

  2018-10-22

  

  Introduction The degree to which embryonic stem buy poly ic (ESCs) represent generic properties of pluripotent founder cells in mammalian embryos is unresolved (Nichols and Smith, 2012; Smith, 2001). Mouse ESCs are the paradigmatic model. However, it is increasingly clear that there are difference

• br Results br Discussion The goal of this study was

  2018-10-22

  

  Results Discussion The goal of this study was to define a quality-control standard rubric for assessing stem cell-derived cardiac myocytes. We chose a set of experimental measurements that provide insight into not only the expression profile of the O4I1 cost but also morphological and functio

• br Acknowledgments Funding for The International Stem Cell I

  2018-10-22

  

  Acknowledgments Funding for The International Stem Cell Initiative and for this meeting were provided by the International Stem Cell Forum (http://www.stem-cell-forum.net). Additional support for the meeting was provided by the Pluripotent Stem Cell Platform, a Hub funded by the UK Regenerative M

• This work was supported by grants from and L S

  2018-10-22

  

  This work was supported by grants from , and . L.S. received fellowship from ANII (Agencia Nacional de Investigación e Innovación, Uruguay); S.G., J.Z. and B.D. from CNPq, P.S., A.C. and M.A.S. from FIOCRUZ. Introduction CXCL12–CXCR4 axis plays important roles during CNS development, controllin

• Potential candidates contributing to the fate determination

  2018-10-22

  

  Potential candidates contributing to the fate determination in the injured spinal cord include bone morphogenetic proteins (BMPs) — in particular BMP2 and BMP4, which strongly promote astroglial differentiation at the expense of oligodendroglial and neuronal differentiation (Bonaguidi et al., 2005;

• Acknowledgments We thank Elisa Ronconi for her assistance

  2018-10-20

  

  Acknowledgments We thank Elisa Ronconi for her assistance in preparing Fig. 1. We thank P Romagnani and G Remuzzi for their comment () on our paper (). The goal of our paper was to obtain a cell population enriched with adult renal stem TAK-875 cost exploiting the self-renewal characteristic, t

• Using quantitative real time PCR a strong reduction of Cdx

  2018-10-20

  

  Using quantitative real-time PCR, a strong reduction of Cdx2 and Klf4 expression levels was found within the first 6h of Nanog induction, demonstrating that Nanog is a direct repressor of these two genes (Figs. 5A–D and S2). ChIP further revealed binding of Nanog to the regulatory elements of Cdx2 a

• Early studies demonstrated that primitive cells are readily

  2018-10-20

  

  Early studies demonstrated that primitive CM-272 are readily converted into iPSCs (Kim et al., 2008; Kleger et al., 2012; Tsai et al., 2011). Thus, we expected that Lgr5+ cells would be susceptible to reprogramming. Unexpectedly, Lgr5+ cells from HFs and MEFs showed more resistance to early reprogr

• We hypothesized that type B astrocytes might be among the

  2018-10-20

  

  We hypothesized that type B astrocytes might be among the other SVZ-derived cell types able to migrate in response to a damage insult. In this study we used Nilo1, a previously characterized mAb that identifies early neural progenitors in the SVZ niche (Del Valle et al., 2010), demonstrating that Ni

• br Resource table br Resource details Spastic paraplegia

  2018-10-20

  

  Resource table Resource details Spastic paraplegia gene type 5 (SPG5) is an autosomal recessive subtype of hereditary spastic paraplegia caused by mutations in CYP7B1, a gene encoding for the cytochrome P-450 oxysterol 7-α-hydroxylase, essential for the liver-specific alternative pathway in bi

• br Funding This work was supported by a

  2018-10-20

  

  Funding This work was supported by a grant from the Dutch Technology Foundation STW (project 10507). Disclosures Acknowledgments Introduction Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia in patients with bilateral lung infiltrates. The Berlin defin

• Identification of the niche and

  2018-10-20

  

  Identification of the niche and phenotype of the first definitive HSCs that emerge in the human embryo is of high importance for elucidating the biology of these liothyronine sodium and investigating the mechanisms that underlie their development and high regenerative potential. However, this analys

• Importantly this recent paper Gonzalez Cordero

  2018-10-20

  

  Importantly, this recent paper (Gonzalez-Cordero et al., 2013) together with our work confirms the capacity of pluripotent stem cells to provide a renewable source of cells to produce photoreceptors in vitro and highlights the great interest of using the 3D culture system developed by Sasai’s group.

• Using the combination of a mitogen activated protein

  2018-10-20

  

  Using the combination of a mitogen-activated protein kinase kinase (MEK) inhibitor, PD0325901 (PD03), and a glycogen synthase kinase 3 (GSK3) inhibitor, CHIR99021 (CHIR), which will hereafter be referred to as 2i, mouse ESCs (mESCs) are maintained in a ground state (Ying et al., 2008). CHIR activate

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