• Sulfo-Cy7 NHS Ester: Transforming NIR Imaging of Microbia...

  2025-09-27

  Discover how Sulfo-Cy7 NHS Ester, a leading sulfonated near-infrared fluorescent dye, is pioneering the sensitive and dynamic imaging of bacterial membrane vesicles and their impact on host biology. This article provides a novel integration of technical mechanisms, comparative analysis, and translational applications, setting it apart as a comprehensive resource for advanced bioimaging.

• Pioglitazone as a Precision PPARγ Modulator: Unraveling M...

  2025-09-26

  Explore how Pioglitazone, a potent PPARγ agonist, uniquely regulates macrophage polarization via STAT signaling, revealing new insights for type 2 diabetes mellitus and inflammatory disease research. This article provides advanced mechanistic analysis and applications distinct from existing resources.

• TAK-242 (Resatorvid): Innovative Strategies for TLR4 Inhi...

  2025-09-25

  Explore the advanced scientific mechanisms and translational applications of TAK-242, a selective TLR4 inhibitor, in neuroinflammation and systemic inflammation research. This article uniquely examines TAK-242’s integration with transcriptional and epigenetic regulation, offering new perspectives for therapeutic development.

• N1-Methyl-Pseudouridine-5'-Triphosphate: Engineering RNA ...

  2025-09-24

  Explore how N1-Methyl-Pseudouridine-5'-Triphosphate revolutionizes RNA synthesis and stability in advanced applications, from decoding translation mechanisms to propelling mRNA vaccine innovation. This in-depth guide highlights unique structural and mechanistic insights not found in standard reviews.

• Torin 1: Mechanistic Insights for Advanced mTOR Pathway S...

  2025-09-23

  Explore how Torin 1, a potent ATP-competitive mTOR inhibitor, enables precise dissection of mTORC1 and mTORC2 signaling in cellular proliferation, autophagy, and lipid metabolism research. This article presents novel perspectives on the integration of Torin 1 in mechanistic studies of mTOR-regulated processes.

• Considering the physicochemical stability results on Fig it

  2025-03-03

  

  Considering the physicochemical stability results on Fig. 5, it was observed that the particles are stable when they are stored at 4 °C for 30 days. After day 30, a significant increase was observed in particle size, but at the end of the 90 days the SLN particle size is still below 100 nm. Stabilit

• br Declaration of interest br Funding br Introduction

  2025-03-01

  

  Declaration of interest Funding Introduction The endocrine disruptor bisphenol A (BPA) is a high-production chemical used in several consumer products, including polycarbonate bottles, epoxy resins, dental sealants, and thermal paper receipts (Geens et al., 2012). Importantly, BPA monomers

• In recent years the higher lipophilicity thus better perform

  2025-03-01

  

  In recent years, the ‘higher lipophilicity’-thus-‘better performance’ tenet, derived from the polar paradox theory applied to micro-structured media, was challenged by novel and unexpected experimental results. In particular, the synthesis of many complete series of fatty transcription factors este

• br Conclusions In summary we report a novel

  2025-03-01

  

  Conclusions In summary, we report a novel preliminary finding of a potential racial difference in the association of Cd-content and AR expression in prostate cancer that will need to be confirmed in larger studies. Although the association of Cd and AR protein expression is not strong in tumor ti

• The major phase trial NCT enrolled participants

  2025-03-01

  

  The major phase 2 trial (NCT01343966) enrolled 431 participants with mild to moderate AD who received either low-dose SC crenezumab 300 mg or placebo biweekly (n = 184) or high-dose intravenous crenezumab 15 mg/kg or placebo every 4 weeks (n = 247) for 68 weeks 38, 40. No significant treatment benef

• We found that decreased Ng

  2025-03-01

  

  We found that decreased Ng levels lead to a lower threshold for LTD induction at L4–L2/3 synapses. Previous studies in hippocampal slice culture have shown that LTD at individual synapses induces spine elimination at both the targeted synapse and selective neighboring synapses when spines are monito

• br Experimental section br Results and discussion

  2025-03-01

  

  Experimental section Results and discussion Conclusion Acknowledgement This work was supported by the National Natural Science Foundation of China (Grant Nos. 81401489), the Shanghai Pujiang Program (17PJ1402800) and the Shanghai Sailing Program (Grant No. 14YF1409000). Introduction

• br Discussion The patient presented

  2025-03-01

  

  Discussion The patient presented initially only with parietal symptoms in the form of acalculia, visuo-spatial deficits, and visuo-perceptual deficits and dressing apraxia. He also had simultognosia as early symptoms. Later when the disease progressed he had recent memory deficits and language in

• ptc chemical br Materials and Methods br Results A

  2025-03-01

  

  Materials and Methods Results A total of 28 NSCLC tumor samples from 26 patients (2 patients with paired tumor samples) were included. According to the initial FISH (Abbott Molecular probes) and IHC results, 13 samples were ALK IHC+FISH+, 5 samples were ALK IHC+FISH−, 2 samples (from the same

• Gliomas and Aldehyde Dehydrogenase Aldehyde

  2025-03-01

  

  Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases (ALDHs) are key metabolic enzymes involved in regulation of glycolysis/gluconeogenesis pathways as well as in the detoxification of endogenous and exogenous aldehydes, regulating cell function and homeostasis. ALDHs play important roles in

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